Biomed Pharmacother. 2018, 103, 1473-1481.
2,7"-Phloroglucinol-6,6'-bieckol protects INS-1 cells against high glucose-induced apoptosis.
Lee HA, Lee JH, Han JS.

J Functional Foods 2018, 46, 356-364.
Supplementation of a polyphenol extract from Ecklonia cava reduces body fat, oxidative and inflammatory stress in overweight healthy subjects with abdominal obesity: A randomized, placebo-controlled, double-blind trial.
Lee HJ, Kwon O, Kim JY.

Food Chem. 2018, 257, 128-134.
Inhibitory activity of minor phlorotannins from Ecklonia cava on α-glucosidase.
Park SR, Kim JH, Jang HD, Yang SY, Kim YH.

Biomol Ther (Seoul). 2018, 26(2), 218-223.
Hepaprotective Effect of Standardized Ecklonia stolonifera Formulation on CCl4-Induced Liver Injury in Sprague-Dawley Rats.
Byun JH, Kim J, Choung SY.

Int J Mol Med. 2018, 41(2), 924-934.
Anti-obesity effects of pectinase and cellulase enzyme‑treated Ecklonia cava extract in high‑fat diet‑fed C57BL/6N mice.
Kim IH, Choi JW, Lee MK, Kwon CJ, Nam TJ.

Pharm Biol. 2017, 55(1), 1149-1154.
A phlorotannin constituent of Ecklonia cava alleviates postprandial hyperglycemia in diabetic mice.
Lee HA, Lee JH, Han JS.

Mar Drugs. 2017, 15(4), 106.
The Effect of Phloroglucinol, A Component of Ecklonia cava Extract, on Hepatic Glucose Production.
Yoon JY, Choi H, Jun HS.

J Pharm Pharmacol. 2017, 69(3), 325-333.
Fucosterol, isolated from Ecklonia stolonifera, inhibits adipogenesis through modulation of FoxO1 pathway in 3T3-L1 adipocytes.
Lee JH, Jung HA, Kang MJ, Choi JS, Kim GD.

Int J Mol Med. 2017, 39(3), 636-644.
Enzyme-treated Ecklonia cava extract inhibits adipogenesis through the downregulation of C/EBPα in 3T3-L1 adipocytes.
Kim IH, Nam TJ.

J Agric Food Chem. 2017, 65(19), 3811-3818.
Ameliorative Effect of Ecklonia cava Polyphenol Extract on Renal Inflammation Associated with Aberrant Energy Metabolism and Oxidative Stress in High Fat Diet-Induced Obese Mice.
Eo H, Park JE, Jeon YJ, Lim Y.

J Agric Food Chem. 2016, 64(27), 5508-5514.
MicroRNA134 Mediated Upregulation of JNK and Downregulation of NFkB Signalings Are Critically Involved in Dieckol Induced Antihepatic Fibrosis.
Lee SY, Lee J, Lee H, Kim B, Lew J, Baek N, Kim SH.

Biomol. Ther. (Seoul) 2016, 24, 650-658.
Protective effects of Ecklonia stolonifera extract on ethanol induced fatty liver in rats.
Bang, CY, Byun JH, Choi HK, Choi JS, Choung SY.

Mar Drugs. 2016, 14(9), 168.
Dioxinodehydroeckol Enhances the Differentiation of Osteoblasts by Regulating the Expression of Phospho-Smad1/5/8.
Ahn BN, Karadeniz F, Kong CS, Nam KH, Jang MS, Seo Y, Kim HS.

Biomed Mater. 2016, 11(4), 045015.
Enrichment of enzymatically mineralized gellan gum hydrogels with phlorotannin-rich Ecklonia cava extract Seanol® to endow antibacterial properties and promote mineralization
Douglas TE, Dokupil A, Reczyńska K, Brackman G, Krok-Borkowicz M, Keppler JK, Božič M, Van Der Voort P, Pietryga K, Samal SK, Balcaen L, van den Bulcke J, Van Acker J, Vanhaecke F, Schwarz K, Coenye T, Pamuła E.

Mol Nutr Food Res. 2015, 59(8), 1458-1471.
Dieckol, a major phlorotannin in Ecklonia cava, suppresses lipid accumulation in the adipocytes of high-fat diet-fed zebrafish and mice: Inhibition of early adipogenesis via cell cycle arrest and AMPKa activation.
Choi HS, Jeon HJ, Lee OH, Lee BY.

J Agric Food Chem. 2015, 63(1), 349-359.
Brown alga Ecklonia cava polyphenol extract ameliorates hepatic lipogenesis, oxidative stress and inflammation by activation of AMPK and SIRT1 in high fat diet-induced obese mice.
Eo H, Jeon YJ, Lee M, Lim Y.

Mar. Drugs 2015, 13, 3877-3891.
Ecklonia cava Polyphenol Has a Protective Effect against Ethanol-Induced Liver Injury in a Cyclic AMP-Dependent Manner.
Yamashita H, Goto M, Matsui-Yuasa I, Kojima-Yuasa A.

Food Funct. 2015, 6(3), 853-858.
Efficacy and safety of a dieckol-rich extract (AG-dieckol) of brown algae, Ecklonia cava, in pre-diabetic individuals: a double-blind, randomized, placebo-controlled clinical trial.
Lee SH, Jeon YJ.

Mar Drugs. 2015, 13(11), 6866-6883.
Polyphenol-Rich Fraction of Ecklonia cava Improves Nonalcoholic Fatty Liver Disease in High Fat Diet-Fed Mice.
Park EY, Choi H, Yoon JY, Lee IY, Seo Y, Moon HS, Hwang JH, Jun HS.

Eur J Pharmacol. 2015, 752, 92-96.
Phlorofucofuroeckol A isolated from Ecklonia cava alleviates postprandial hyperglycemia in diabetic mice.
You HN, Lee HA, Park MH, Lee JH, Han JS.

Molevcules 2015, 20(12), 21715-21731.
Seapolynol Extracted from Ecklonia cava Inhibits Adipocyte Differentiation in Vitro and Decreases Fat Accumulation in Vivo.
Jeon HJ, Choi HS, Lee YJ, Hwang JH, Lee OH, Seo MJ, Kim KJ, Lee BY.

J Food Nutr Res. 2015, 3(10), 648-652.
Seapolynol and Dieckol Improve Insulin Sensitivity through the Regulation of the PI3K Pathway in C57BL/KsJ-db/db Mice.
Jeon HJ, Yoon KY, Koh EJ, Choi J, Kim KJ, Choi HS, Lee BY.

J Sci Food Agric. 2015, 95(3), 1830-1837.
6,6'-Bieckol inhibits adipocyte differentiation through downregulation of adipogenesis and lipogenesis in 3T3-L1 cells.
Kwon TH, Wu YX, Kim JS, Woo JH, Park KT, Kwon OJ, Seo HJ, Kim T, Park NH.

Appl Biochem Biotechnol. 2014, 174(2), 632-643.
6,6'-Bieckol Isolated from Ecklonia cava Protects Oxidative Stress Through Inhibiting Expression of ROS and Proinflammatory Enzymes in High-Glucose-Induced Human Umbilical Vein Endothelial Cells.
Park MH, Heo SJ, Park PJ, Moon SH, Sung SH, Jeon BT, Lee SH.

Prev Nutr Food Sci. 2014, 19(3), 170-177.
Effect of Baechu Kimchi Added Ecklonia cava Extracts on High Glucose-induced Oxidative Stress in Human Umbilical Vein Endothelial Cells.
Lee HA, Song YO, Jang MS, Han JS.

Fitoterapia. 2014, 92, 260-269.
Phlorotannins isolated from the edible brown alga Ecklonia stolonifera exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBPα and PPARγ.
Jung HA, Jung HJ, Jeong HY, Kwon HJ, Ali MY, Choi JS.

Biosci Biotechnol Biochem. 2014, 78(5), 832-838.
A high-throughput screen for inhibitors of the prolyl isomerase, Pin1, identifies a seaweed polyphenol that reduces adipose cell differentiation.
Mori T, Hidaka M, Ikuji H, Yoshizawa I, Toyohara H, Okuda T, Uchida C, Asano T, Yotsu-Yamashita M, Uchida T.

Environ Toxicol Pharmacol. 2014, 38(2), 607-615.
Octaphlorethol A isolated from Ishige foliacea prevents and protects against high glucose-induced oxidative damage in vitro and in vivo.
Kang MC, Kim KN, Chaminda Lakmal HH, Kim EA, Wijesinghe WA, Yang X, Heo SJ, Jeon YJ.

J Pharm Pharmacol. 2014, 66(8), 1180-1188.
Protective effect of the edible brown alga Ecklonia stolonifera on doxorubicin-induced hepatotoxicity in primary rat hepatocytes.
Jung HA, Kim JI, Choung SY, Choi JS.

Arch Pharm Res. 2014, 37(6), 713-720.
Anti-adipogenic activity of the edible brown alga Ecklonia stolonifera and its constituent fucosterol in 3T3-L1 adipocytes.
Jung HA, Jung HJ, Jeong HY, Kwon HJ, Kim MS, Choi JS.

Environ Toxicol Pharmacol. 2013, 36(3), 1217-1226.
Protective effect of dieckol isolated from Ecklonia cava against ethanol caused damage in vitro and in zebrafish model.
Kang MC, Kim KN, Kang SM, Yang X, Kim EA, Song CB, Nah JW, Jang MK, Lee JS, Jung WK, Jeon YJ.

Food Chem Toxicol. 2013, 53, 294-298.
Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db/db mouse model.
Kang MC, Wijesinghe WA, Lee SH, Kang SM, Ko SC, Yang X, Kang N, Jeon BT, Kim J, Lee DH, Jeon YJ.

Environ Toxicol Pharmacol. 2013, 36(3), 1253-1260.
Dieckol, a phlorotannin isolated from a brown seaweed, Ecklonia cava, inhibits adipogenesis through AMP-activated protein kinase (AMPK) activation in 3T3-L1 preadipocytes.
Ko SC, Lee M, Lee JH, Lee SH, Lim Y, Jeon YJ.

Prev Nutr Food Sci. 2013, 18(3), 163-168.
Alleviating Effects of Baechu Kimchi Added Ecklonia cava on Postprandial Hyperglycemia in Diabetic Mice.
Lee HA, Song YO, Jang MS, Han JS.

Chem Biol Interact. 2013, 206(1), 55-62.
Kinetics and molecular docking studies of an anti-diabetic complication inhibitor fucosterol from edible brown algae Eisenia bicyclis and Ecklonia stolonifera.
Jung HA, Islam MN, Lee CM, Oh SH, Lee S, Jung JH, Choi JS.

Environ Toxicol Pharmacol. 2013, 35(3), 395-401.
Protective effect of phlorotannins from Eisenia bicyclis against lipopolysaccharide-stimulated inflammation in HepG2 cells.
Kang YM, Eom SH, Kim YM.

J Agric Food Chem. 2013, 61(36), 8541-8547.
Evaluation of Inhibitory Effect of Phlorotannins from Ecklonia cava on Triglyceride Accumulation in Adipocyte.
Kim H, Kong CS, Lee JI, Kim H, Baek S, Seo Y.

Biosci Biotechnol Biochem. 2012, 76(8), 1445-1451.
Dieckol Isolated from Ecklonia cava Protects against High-Glucose Induced Damage to Rat Insulinoma Cells by Reducing Oxidative Stress and Apoptosis.
Lee SH, Park MH, Kang SM, Ko SC, Kang MC, Cho S, Park PJ, Jeon BT, Kim SK, Han JS, Jeon YJ.

Food Chem Toxicol. 2012, 50(3-4), 575-582.Effects of brown alga, Ecklonia cava on glucose and lipid metabolism in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus.
Lee SH, Min KH, Han JS, Lee DH, Park DB, Jung WK, Park PJ, Jeon BT, Kim SK, Jeon YJ.

Asian Pac J Trop Med. 2012, 5(5), 374-379.
Insulinotrophic and hypolipidemic effects of Ecklonia cava in streptozotocin-induced diabetic mice.
Kim MJ, Kim HK.

Evid Based Complement Alternat Med. 2012, 2012, 439294.
Ecklonia cava Inhibits Glucose Absorption and Stimulates Insulin Secretion in Streptozotocin-Induced Diabetic Mice.
Kim HK.

Appl Biochem Biotechnol. 2012, 167, 1973-1985.
Bioactive Compounds Extracted from Ecklonia cava by Using Enzymatic Hydrolysis Protects High Glucose-Induced Damage in INS-1 Pancreatic β-Cells.
Lee SH, Park MH, Park SJ, Kim J, Kim YT, Oh MC, Jeong Y, Kim M, Han JS, Jeon YJ.

Int J Biomed Sci. 2012, 8(1), 64-75.
Effects of Gametophytes of Ecklonia Kurome on the Levels of Glucose and Triacylglycerol in db/db, Prediabetic C57BL/6J and IFN-γ KO Mice.
Dwiranti F, Hiraoka M, Taguchi T, Konishi Y, Tominaga M, Tominaga A.

Fitoterapia. 2012, 83, 1060-1067.
Cytoprotective effects of phlorofucofuroeckol A isolated from Ecklonia stolonifera against tacrine-treated HepG2 cells.
Lee MS, Kim JI, Utsuki T, Park NG, Kim HR.

J Sci Food Agric. 2012, 92(10), 2084-2090.
α-Glucosidase- and α-amylase-inhibitory activities of phlorotannins from Eisenia bicyclis.
Eom SH, Lee SH, Yoon NY, Jung WK, Jeon YJ, Kim SK, Lee MS, Kim YM.

Phytother Res. 2012, 27, 148-151.
Pancreatic Lipase Inhibitory Activity of Phlorotannins Isolated from Eisenia bicyclis.
Eom SH, Lee MS, Lee EW, Kim YM, Kim TH.

Pharm Biol. 2012, 50(3), 393-400.
Antidiabetic effect of polyphenols from brown alga Ecklonia kurome in genetically diabetic KK-A(y) mice.
Xu HL, Kitajima C, Ito H, Miyazaki T, Baba M, Okuyama T, Okada Y.

J Agric Food Chem. 2012, 60(21), 5340-5349.
Isolation and Identification of Phlorotannins from Ecklonia stolonifera with Antioxidant and Hepatoprotective Properties in Tracrine-Treated HepG2 Cells.
Lee MS, Shin TS, Utsuki T, Choi JS, Byun DS, Kim HR.

Food Chem Toxicol. 2012, 50(6), 1986-1991.
Hepatoprotective effects of dieckol-rich phlorotannins from Ecklonia cava, a brown seaweed, against ethanol induced liver damage in BALB/c mice.
Kang MC, Ahn G, Yang X, Kim KN, Kang SM, Lee SH, Ko SC, Ko JY, Kim D, Kim YT, Jee Y, Park SJ, Jeon YJ.

Evid Based Complement Alternat Med. 2012, 2012, 418912.
Polyphenol-Rich Fraction of Brown Alga Ecklonia cava Collected from Gijang, Korea, Reduces Obesity and Glucose Levels in High-Fat Diet-Induced Obese Mice.
Park EY, Kim EH, Kim MH, Seo YW, Lee JI, Jun HS.

Prev Nutr Food Sci. 2012, 17, 1-7.
Anti-hyperlipidemic Effect of Polyphenol Extract (SeapolynolTM) and Dieckol Isolated from Ecklonia cava in in vivo and in vitro Models.
Yeo AR, Lee J, Tae IH, Park SR, Cho YH, Lee BH, Shin HC, Kim SH, Yoo YC.

Phytother Res. 2012, 26(3), 363-368.
Effects of 12-week Oral Supplementation of Ecklonia cava Polyphenols on Anthropometric and Blood Lipid Parameters in Overweight Korean Individuals: A Double-blind Randomized Clinical Trial.
Shin HC, Kim SH, Park Y, Lee BH, Hwang HJ.

J Med Food. 2012, 15(11), 1038-1044.
Effects of Ecklonia cava Polyphenol in Individuals with Hypercholesterolemia: A Pilot Study.
Lee DH, Park MY, Shim BJ, Youn HJ, Hwang HJ, Shin HC, Jeon HK.

Biochim Biophys Acta. 2012, 1820, 978-988.
Ecklonia cava polyphenol protects the liver against ethanol-induced injury in rats.
Takahashi M, Satake N, Yamashita H, Tamura A, Sasaki M, Matsui-Yuasa I, Tabuchi M, Akahoshi Y, Terada M, Kojima-Yuasa A.

Mar Drugs. 2011, 9(12), 2793-2808.
Inhibitory Effects of Ecklonia cava Extract on High Glucose-Induced Hepatic Stellate Cell Activation.
Yokogawa K, Matsui-Yuasa I, Tamura A, Terada M, Kojima-Yuasa A.

Appl Biochem Biotechnol. 2011, 165(5-6), 1296-1307.
Isolation of Phlorotannins from Eisenia bicyclis and Their Hepatoprotective Effect against Oxidative Stress Induced by tert-Butyl Hyperoxide.
Kim SM, Kang K, Jeon JS, Jho EH, Kim CY, Nho CW, Um BH.

Biosci Biotechnol Biochem. 2011, 75(8), 1472-1480.
Protein Tyrosine Phosphatase 1B and α-Glucosidase Inhibitory Phlorotannins from Edible Brown Algae, Ecklonia stolonifera and Eisenia bicyclis.
Moon HE, Islam N, Ahn BR, Chowdhury SS, Sohn HS, Jung HA, Choi JS.

Food Chem Toxicol. 2010, 48(2), 509-516.
Brown alga Ecklonia cava attanuates type 1 diabetes by activation AMPK and Ark signaling pathways.
Kang C, Jin YB, Lee H, Cha M, Sohn ET, Moon J, Park C, Chun S, Jung ES, Hong JS, Kim SB, Kim JS, Kim E.

Int J Sport Nutr Exerc Metab. 2010, 20(1), 72-79.
Effect of Supplementation With Ecklonia cava Polyphenol on Endurance Performance of College Students.
Oh JK, Shin YO, Yoon JH, Kim SH, Shin HC, Hwang HJ.

Food Chem Toxicol. 2010, 48(10), 2633-2637.
Dieckol isolated from Ecklonia cava inhibits alpha-glucosidase and alpha-amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice.
Lee SH, Park MH, Heo SJ, Kang SM, Ko SC, Han JS, Jeon YJ.

Chem Biol Interact. 2010, 186(1), 24-29.
Anti-adipogenic effect of dioxinodehydroeckol via AMPK activation in 3T3-L1 adipocytes.
Kim SK, Kong CS.

Mar Biotechnol (NY). 2010, 12(3), 299-307.
1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin inhibits adipocyte differentiation of 3T3-L1 fibroblasts.
Kong CS, Kim JA, Ahn BN, Vo TS, Yoon NY, Kim SK.

J Sci Food Agric. 2009, 89(9), 1552-1558.
α-Glucosidase and α-amylase inhibitory activities of phloroglucinal derivatives from edible marine brown alga, Ecklonia cava.
Lee SH, Li Y, Karadeniz F, Kim MM, Kim SK.

Arch Pharm Res. 2008, 31(12), 1564-1571.
Anti-hyperlipidemic dffect of an edible brown algae, Ecklonia stolonifera, and its constituents on poloxamer 407-induced hyperlipidemic and cholesterol-fed rats.
Yoon NY, Kim HR, Chung HY, Choi JS.

Plant Foods Hum Nutr. 2008, 63(4), 163-169.
Antidiabetic antioxidant effects of polyphenols in brown alga Ecklonia stolonifera in genetecally diabetic
KK-Ay mice.
Iwai K.

Arch Pharm Res. 2005, 28(12), 1376-1380.
Hepatoprotective constituents of the edible brown alga Ecklonia stolonifera on tacrine- induced cytotoxicity in Hep G2 cells.
Kim YC, An RB, Yoon NY, Nam TJ, Choi JS.

J Nat Prod. 2004, 67(1), 103-105.
A new phloroglucinol derivative from the brown alga Eisenia bicyclis: potential for the effective treatment of diabetic complications.
Okada Y, Ishimaru A, Suzuki R, Okuyama T.

Eur. J. Phycol. 2002, 37, 493-500.
Inhibitory activity of brown algal phlorotannins against glycosidases from the viscera of the turban shell Turbo cornutus.
Shibata T, Yamaguchi K, Nagayama K, Kawaguchi S, Nakamura T.