Front Mol Neurosci. 2023;16:1193590.
Therapeutic effects of phlorotannins in the treatment of neurodegenerative disorders.
Kwon YJ, Kwon OI, Hwang HJ, Shin HC, Yang S.

Mar Drugs. 2021 Jul 29;19(8):434.
Mixture of Phlorotannin and Fucoidan from Ecklonia cava Prevents the Abeta-Induced Cognitive Decline with Mitochondrial and Cholinergic Activation.
Han HJ, Park SK, Kang JY, Kim JM, Yoo SK, Kim DO, Kim GH, Heo HJ.

J Pharmacol Sci. 2021 Apr;145(4):308-312.
Phloroglucinol attenuates oligomeric amyloid beta peptide1-42-induced astrocytic activation by reducing oxidative stress.
Yang EJ, Kim H, Kim HS, Chang MJ.

J Microbiol Biotechnol. 2021 Apr 28;31(4):584-591.
Effects of Ecklonia cava Extract on Neuronal Damage and Apoptosis in PC-12 Cells against Oxidative Stress.
Shin YS, Kim KJ, Park H, Lee MG, Cho S, Choi SI, Heo HJ, Kim DO, Kim GH.

Mar Drugs. 2021 Feb 27;19(3):131.
Ecklonia cava Attenuates PM(2.5)-Induced Cognitive Decline through Mitochondrial Activation and Anti-Inflammatory Effect.
Park SK, Kang JY, Kim JM, Kim HJ, Heo HJ.

Food Funct. 2020 Jul 22;11(7):6509-6516.
Ecklonia radiata extract containing eckol protects neuronal cells against Aβ(1-42) evoked toxicity and reduces aggregate density.
Shrestha S, Zhang W, Begbie AJ, Pukala TL, Smid SD.

Mar Drugs. 2019 Jun 24;17(6):377.
Probing Multi-Target Action of PhlorotanninsHere is the continuation of the HTML code: ```html as New Monoamine Oxidase Inhibitors and Dopaminergic Receptor Modulators with the Potential for Treatment of Neuronal Disorders.
Seong SH, Paudel P, Choi JW, Ahn DH, Nam TJ, Jung HA, Choi JS.

Pharm Biol. 2019 Dec;57(1):460-469.
Phenolic composition, antioxidant activity, anticholinesterase potential and modulatory effects of aqueous extracts of some seaweeds on β-amyloid aggregation and disaggregation.
Olasehinde TA, Olaniran AO, Okoh AI.

Marine Drugs. 2019 Oct 23;17(11).
Identifying Phlorofucofuroeckol-A as a Dual Inhibitor of Amyloid-β25-35 Self-Aggregation and Insulin Glycation: Elucidation of the Molecular Mechanism of Action.
Seong SH, Paudel P, Jung HA, Choi JS.

J Food Biochem. 2019 Jul;43(7):e12870.
Aqueous-ethanol extracts of some South African seaweeds inhibit beta-amyloid aggregation, cholinesterases, and beta-secretase activities in vitro.
Olasehinde TA, Olaniran AO, Okoh AI.

Metab Brain Dis. 2019 Jul 26.
Neuroprotective effects of some seaweeds against Zn-induced neuronal damage in HT-22 cells via modulation of redox imbalance, inhibition of apoptosis and acetylcholinesterase activity.
Olasehinde TA, Olaniran AO, Okoh AI.

Free Radic Biol Med. 2018 Oct;126:221-234.
Phloroglucinol ameliorates cognitive impairments by reducing the amyloid β peptide burden and pro-inflammatory cytokines in the hippocampus of 5XFAD mice.
Yang EJ, Mahmood U, Kim H, Choi M, Choi Y, Lee JP, Cho JY, Hyun JW, Kim YS, Chang MJ, Kim HS.

Korean J Physiol Pharmacol. 2019, 23(2), 121-130.
Neuroprotective mechanisms of dieckol against glutamate toxicity through reactive oxygen species scavenging and nuclear factor-like 2/heme oxygenase-1 pathway.
Cui Y, Amarsanaa K, Lee JH, Rhim JK, Kwon JM, Kim SH, Park JM, Jung SC, Eun SY.

Mar Drugs. 2019, 17(2), 108.
Eckol as a Potential Therapeutic against Neurodegenerative Diseases Targeting Dopamine D₃/D₄ Receptors.
Paudel P, Seong SH, Wu S, Park S, Jung HA, Choi JS.

Nutr Neurosci. 2019, 22(8), 551-568.
Nutraceuticals to promote neuronal plasticity in response to corticosterone-induced stress in human neuroblastoma cells.
Gite S, Ross RP, Kirke D, Guihéneuf F, Aussant J, Stengel DB, Dinan TG, Cryan JF, Stanton C.

ACS Chem Neurosci. 2018, 9(6), 1349-1356.
Eckmaxol, a phlorotannin extracted from Ecklonia maxima, produces anti-β-amyloid oligomer neuroprotective effects possibly via directly acting on glycogen synthase kinase 3β.
Wang J, Zheng J, Huang C, Zhao J, Lin J, Zhou X, Naman CB, Wang N, Gerwick WH, Wang Q, Yan X, Cui W, He S.

Arch Pharm Res. 2017, 40(4), 480-491.
Evaluation of the inhibitory effects of eckol and dieckol isolated from edible brown alga Eisenia bicyclis on human monoamine oxidases A and B.
Jung HA, Roy A, Jung JH, Choi JS.

Immunopharmacol Immunotoxicol. 2016, 38(3), 244-252.
6,6'-Bieckol suppresses inflammatory responses by down-regulating nuclear factor-κB activation via Akt, JNK, and p38 MAPK in LPS-stimulated microglial cells.
Kim AR, Lee B, Joung EJ, Gwon WG, Utsuki T, Kim NG, Kim HR.

Korean J Physiol Pharmacol. 2015, 19(3), 219-228.
Dieckol Attenuates Microglia-mediated Neuronal Cell Death via ERK, Akt and NADPH Oxidase-mediated Pathways.
Cui Y, Park JY, Wu J, Lee JH, Yang YS, Kang MS, Jung SC, Park JM, Yoo ES, Kim SH, Ahn Jo S, Suk K, Eun SY.

Phytother Res . 2015. 29(4), 549-553.
Multifunctional Activity of Polyphenolic Compounds Associated with a Potential for Alzheimer's Disease Therapy from Ecklonia cava.
Choi BW, Lee HS, Shin HC, Lee BH.

Biomaterials 2015, 61, 52-60.
Blood-brain barrier-permeable fluorone-labeled dieckols acting as neuronal ER stress signaling inhibitors.
Kwak JH, Yang Z, Yoon B, He Y, Uhm S, Shin HC, Lee BH, Yoo YC, Lee KB, Han SY, Kim JS.

Arch Pharm Res. 2015, 38(8), 1477-1487.
Acetyl- and butyryl-cholinesterase inhibitory activities of the edible brown alga Eisenia bicyclis. Arch Pharm Res.
Choi JS, Haulader S, Karki S, Jung HJ, Kim HR, Jung HA.

Fish Aquat Sci. 2014, 17(1), 19-25.
Sleep-Promoting Effect of Ecklonia cava: Ethanol Extract Promotes Non-rapid Eye Movement Sleep in C57BL/6N Mice.
Yoon M, Kim JS, Jo J, Han D, Cho S.

Molecules. 2014, 19(6), 7669-7678.
The Edible Brown Seaweed Ecklonia cava Reduces Hypersensitivity in Postoperative and Neuropathic Pain Models in Rats.
Kim JG, Lim DW, Cho S, Han D, Kim YT.

Kor J Herbology 2014, 29(6), 103-109.
Effect of Ecklonia cava Extracts Supplementation on cognitive ability in mice.
Oh JK, Song KJ, Ji MY, Yoon JH.

Psychopharmacology (Berl). 2014, 231(14), 2825-2837.
Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor.
Cho S, Yoon M, Pae AN, Jin YH, Cho NC, Takata Y, Urade Y, Kim S, Kim JS, Yang H, Kim J, Kim J, Han JK, Shimizu M, Huang ZL.

Food Research Internatioanl. 2013, 54, 1250-1254.
Acetylcholinesterase inhibitory activity of phlorotannins isolated form the brown alga, Ecklonia maxima (Osbeck) Papenfuss.
Kannan, R.R.R., Aderogba, M.A., Ndhlala, A.R., Stirk, W.A., Van Staden, J.

Inflammation. 2013, 36(2), 259-271.
Phlorofucofuroeckol A Suppresses Expression of Inducible Nitric Oxide Synthase, Cyclooxygenase-2, and Pro-inflammatory Cytokines via Inhibition of Nuclear Factor-κB, c-Jun NH(2)-Terminal Kinases, and Akt in Microglial Cells.
Kim AR, Lee MS, Choi JW, Utsuki T, Kim JI, Jang BC, Kim HR.

Neurotoxicology. 2013, 34, 16-24.
Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity.
Kang IJ, Jang BG, In S, Choi B, Kim M, Kim MJ.

PhD Thesis, 2012,
Department of Physiology, Graduate School, Jeju Natioanl University.Neuroprotective Mechanisms of Antioxidant Dieckol against Microglia-mediated Neurotoxicity and Mitochondrial-dependent Neuronal Cell Death.
Cui YJ.

Arch Pharm Res. 2012, 35(11), 1989-1998.
Neuroprotective effect of edible brown alga Eisenia bicyclis on amyloid beta peptide-induced toxicity in PC12 cells.
Ahn BR, Moon HE, Kim HR, Jung HA, Choi JS.

Environ Toxicol Pharmacol. 2012, 34(1), 96-105.
Neuroprotective effects of phlorotannins isolated from a brown alga, Ecklonia cava, against H(2)O(2)-induced oxidative stress in murine hippocampal HT22 cells.
Kang SM, Cha SH, Ko JY, Kang MC, Kim D, Heo SJ, Kim JS, Heu MS, Kim YT, Jung WK, Jeon YJ.

Biosci Biotechnol Biochem. 2012, 76(1), 163-168.
Depressive Effects on the Central Nervous System and Underlying Mechanism of the Enzymatic Extract and Its Phlorotannin-Rich Fraction from Ecklonia cava Edible Brown Seaweed.
Cho S, Han D, Kim SB, Yoon M, Yang H, Jin YH, Jo J, Yong H, Lee SH, Jeon YJ, Shimizu M.

Anat Cell Biol. 2012, 45(2), 103-113.
Protective efficacy of an Ecklonia cava extract used to treat transient focal ischemia of the rat brain.
Kim JH, Lee NS, Jeong YG, Lee JH, Kim EJ, Han SY.

Biosci Biotechnol Biochem. 2011, 75(8), 1472-1480.
Protein tyrosine phosphatase 1B and α-glucosidase inhibitory Phlorotannins from edible brown algae, Ecklonia stolonifera and Eisenia bicyclis.
Moon HE, Islam N, Ahn BR, Chowdhury SS, Sohn HS, Jung HA, Choi JS.

Food Chem Toxicol. 2011, 49(9), 2252-2259.
Butanol extract of Ecklonia cava prevents production and aggregation of beta-amyloid, and reduces beta-amyloid mediated neuronal death.
Kang IJ, Jeon YE, Yin XF, Nam JS, You SG, Hong MS, Jang BG, Kim MJ.

Bioorg Med Chem Lett . 2010, 20(11), 3211-3215.
Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity.
Jung HA, Oh SH, Choi JS.

J Agric Food Chem. 2009, 57(10), 4439-4446.
Inhibitory effects and molecular mechanism of dieckol isolated from marine brown alga on COX-2 and iNOS in microglial cells.
Jung WK, Heo SJ, Jeon YJ, Lee CM, Park YM, Byun HG, Choi YH, Park SG, Choi IW.

Food Chem Toxicol. 2009, 47(2), 410-407.
Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-kB pathways.
Jung WK, Ahn YW, Lee SH, Choi YH, Kim SK, Choi I, Park AG, Seo SK, Lee SW, Choi IW.

Fisheries Science. 2008, 74, 200-207.
Acetyl- and butyrylcholinesterase inhibitory activities of sterols and phlorotannins from Ecklonia Stolonifera.
Yoon NY, Chung HY, Kim HR, Choi JA.

Arch Pharm Res. 2005, 28(6), 691-698.
Improvement of memory by dieckol and phlorofucofuroeckol in ethanol-treated mice: possible involvement of the inhibition of acetylcholinesterase.
Myung CS, Shin HC, Bao HY, Yeo SJ, Lee BH, Kang JS.

Korean J Food Sci Technol. 2004, 36(6), 974-978.
Improvement of Learning Behavior of Mice by an Antiacetylcholinesterase and Neuroprotective Agent NX42, a Laminariales-Alga Extract.
Lee BH, Stein SM.

Research Note.2003.
Summary Note for the Effect of Ecklonia cava Extract in Cognitive Function as Measured by MMSE in Eldery Subjects.
Lee BH, Shin HC.

Research Note. 2002.
Down regulation of beta-APP by LSL4692 (Ecklonia cava polyphenol).
Lee BH.

Research Note. 2001.
Neuroprotection from beta-Amyloid Toxicity by Ecklonia cava Extract.
Lee BH, Shin HC.